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¸£Àû±ÆÕ¾ Catalog 2023-2024

Toxicology (TOX)

This is an archived copy of the 2023-2024 catalog. To access the most recent version of the catalog, please visit .

°Õ°¿³ÝÌý201ÌýÌýPoisons, People and the EnvironmentÌýÌý(3 credit hours)ÌýÌý

°Õ°¿³ÝÌý201 serves as an introduction to the fascinating world of chemical poisons and covers their numerous and varied effects on human health and the environment. We will learn how and why poisons have played an important history, how to critically evaluate the chemical risk information reported in the media, in addition to the underlying principles of the basic science of poisons.

GEP Natural Sciences

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý400ÌýÌýUndergraduate Seminar in ToxicologyÌýÌý(1 credit hours)ÌýÌý

In this seminar course students will be exposed to different presenters each week who will speak on current topics in toxicology, presenting their research on that topic in a broader context. Specific topic areas will vary from semester to semester, but will always be relevant to environmental and molecular toxicology. Students will be expected to write two 1-2 page reflection essays over the course of the semester and participate in a current events in toxicology discussion forum.

Restriction: 17ETM Only

Typically offered in Spring only

°Õ°¿³ÝÌý401/°Õ°¿³ÝÌý501ÌýÌýPrinciples of ToxicologyÌýÌý(4 credit hours)ÌýÌý

Introduce students to the basic principles of toxicology. Will cover the history and scope of the field; absorption, distribution, metabolism and elimination of toxicants; types and mechanisms of toxic action; carcinogenesis; environmental toxicology as well as human and ecological risk assessment.

Typically offered in Spring only

°Õ°¿³ÝÌý415ÌýÌýEnvironmental Toxicology and ChemistryÌýÌý(4 credit hours)ÌýÌý

Environmental toxicology and chemistry including the sources, fate, and effects of chemicals in the environment. Emphasis on contemporary problems in human health and the environment.

Prerequisite: °ä±áÌý220 or °ä±áÌý221 or °ä±áÌý225; µþ±õ°¿Ìý181 or ZO 160 recommended

Typically offered in Fall and Spring

°Õ°¿³ÝÌý501/°Õ°¿³ÝÌý401ÌýÌýPrinciples of ToxicologyÌýÌý(4 credit hours)ÌýÌý

Introduce students to the basic principles of toxicology. Will cover the history and scope of the field; absorption, distribution, metabolism and elimination of toxicants; types and mechanisms of toxic action; carcinogenesis; environmental toxicology as well as human and ecological risk assessment.

Typically offered in Spring only

°Õ°¿³ÝÌý515ÌýÌýEnvironmental ToxicologyÌýÌý(4 credit hours)ÌýÌý

Evaluation of the nature, distribution and significance of microchemical contamination. Emphasis on current, relevant problems.

Prerequisite: Two years of biology

°Õ°¿³ÝÌý558/¹ó³§Ìý558/±·°Õ¸éÌý558ÌýÌýFood ToxicologyÌýÌý(3 credit hours)ÌýÌý

This course evaluates the weight of evidence from peer-reviewed scientific literature relating the presence of chemical or biological toxins, whether naturally occurring or man-made in the food system to health outcomes. Toxicological data are viewed in the context of processing effects, global food and supplement regulations, as well as commercial marketing claims and sustainability. Key concepts include dose-response, phase I and phase I metabolism, signal transduction, and the use of advanced technologies such as genomics, proteomics, and metabolomics. Students will work in teams to develop and write a critical review manuscript suitable for publication.

Prerequisite: Graduate standing or advanced undergraduate students enrolled in Food Science, Nutrition, or Toxicology majors.

Typically offered in Fall only

°Õ°¿³ÝÌý595ÌýÌýSpecial TopicsÌýÌý(1-6 credit hours)ÌýÌý
°Õ°¿³ÝÌý601ÌýÌýToxicology SeminarÌýÌý(1 credit hours)ÌýÌý

Prerequisite: Graduate standing

Typically offered in Fall and Spring

°Õ°¿³ÝÌý620ÌýÌýSpecial ProblemsÌýÌý(1-6 credit hours)ÌýÌý

Topics include responsibility in science, environmental fate of chemicals, developmental toxicology, lab rotations, journal club and wildlife toxicology.

Prerequisite: Graduate standing

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý660ÌýÌýFree Radicals In ToxicologyÌýÌý(1 credit hours)ÌýÌý

Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms.

Typically offered in Fall only

°Õ°¿³ÝÌý688ÌýÌýNon-Thesis Masters Continuous Registration - Half Time RegistrationÌýÌý(1 credit hours)ÌýÌý

For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain half-time continuous registration to complete incomplete grades, projects, final master's exam, etc.

Prerequisite: Master's student

Typically offered in Spring only

°Õ°¿³ÝÌý689ÌýÌýNon-Thesis Master Continuous Registration - Full Time RegistrationÌýÌý(3 credit hours)ÌýÌý

For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain full-time continuous registration to complete incomplete grades, projects, final master's exam, etc. Students may register for this course a maximum of one semester.

Prerequisite: Master's student

Typically offered in Spring only

°Õ°¿³ÝÌý690ÌýÌýMaster's ExamÌýÌý(1-9 credit hours)ÌýÌý

For students in non thesis master's programs who have completed all other requirements of the degree except preparing for and taking the final master's exam.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý693ÌýÌýMaster's Supervised ResearchÌýÌý(1-9 credit hours)ÌýÌý

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý695ÌýÌýMaster's Thesis ResearchÌýÌý(1-9 credit hours)ÌýÌý

Thesis research.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý696ÌýÌýSummer Thesis ResearchÌýÌý(1 credit hours)ÌýÌý

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

Prerequisite: Master's student

Typically offered in Summer only

°Õ°¿³ÝÌý699ÌýÌýMaster's Thesis PreparationÌýÌý(1-9 credit hours)ÌýÌý

For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their theses.

Prerequisite: Master's student

Typically offered in Spring and Summer

°Õ°¿³ÝÌý701ÌýÌýFundamentals of ToxicologyÌýÌý(3 credit hours)ÌýÌý

The basis of toxic action at cellular and molecular levels covering the absorption, distribution, elimination and metabolism of toxicants; toxic action (acute toxicity, carcinogenesis, mutagenesis, organ toxicity, etc.); chemical classes of toxicants; and toxicity testing.

Prerequisite: µþ°ä±áÌý451, Senior standing or Graduate standing

Typically offered in Fall only

°Õ°¿³ÝÌý704ÌýÌýChemical Risk AssessmentÌýÌý(1 credit hours)ÌýÌý

Concepts and vocabulary of risk assessment. Risk assessment models and techniques used in cancer and non-cancer risk assessment and strategies for successful risk communications. Case studies of risk assessment and issues of current interest. Utilization of background in toxicology and statistics to examine a critical end-point in toxicological science, the quantitative risk assessment.

Prerequisite: °Õ°¿³ÝÌý701, a ST course

°Õ°¿³ÝÌý710ÌýÌýMolecular and Biochemical ToxicologyÌýÌý(3 credit hours)ÌýÌý

Fundamental understanding of biochemical, molecular and cellular mechanisms through which xenobiotics alter cellular homeostasis, produce toxicity and alter organ function. Current biochemical, molecular and cellular experimental approaches for study of biochemical mechanisms of toxicity.

Typically offered in Spring only

°Õ°¿³ÝÌý715ÌýÌýEnvironmental ToxicologyÌýÌý(3 credit hours)ÌýÌý

Evaluation of fundamental processes relating fate and effects of chemicals in the environment. Emphasis on effects of pollutants on non-human species, environmental risk assessment and historically relevant incidents of environmental contaminants.

Prerequisite: Two years of biology

Typically offered in Fall only

°Õ°¿³ÝÌý725/°ä³§Ìý725/±á³§Ìý725/³§³§°äÌý725ÌýÌýPesticide ChemistryÌýÌý(1 credit hours)ÌýÌý

Chemical properties of pesticides including hydration and solvation, ionization, volatilization, lipophilicity, molecular structure and size, and reactivity and classification according to chemical description, mode of action or ionizability. Taughtduring the first 5 weeks of semester. Drop date is last day of 3rd week of the minicourse.

Typically offered in Spring only

°Õ°¿³ÝÌý727/°ä³§Ìý727/±á³§Ìý727/³§³§°äÌý727ÌýÌýPesticide Behavior and Fate In the EnvironmentÌýÌý(2 credit hours)ÌýÌý

Sorption/desorption, soil reactivity, movement, volatilization, bioavailability, degradation and stability of pesticides in the environment. Taught during the last 10 weeks of semester. Drop date is last day of 3rd week of the minicourse.

Prerequisite: CS(HS,SSC,TOX) 725,³§³§°äÌý200

Typically offered in Spring only

°Õ°¿³ÝÌý795ÌýÌýSpecial Topics in ToxicologyÌýÌý(1-6 credit hours)ÌýÌý

Typically offered in Fall and Spring

°Õ°¿³ÝÌý801ÌýÌýToxicology SeminarÌýÌý(1 credit hours)ÌýÌý

Prerequisite: Graduate standing

Typically offered in Fall and Spring

°Õ°¿³ÝÌý820ÌýÌýSpecial Problems In ToxicologyÌýÌý(1-6 credit hours)ÌýÌý

Topics include responsibility in science, environmental fate of chemicals, developmental toxicology, lab rotations, Journal Club, and wildlife toxicology.

Prerequisite: Graduate standing

Typically offered in Fall and Spring

°Õ°¿³ÝÌý860ÌýÌýFree Radicals in ToxicologyÌýÌý(1 credit hours)ÌýÌý

Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms.

Typically offered in Fall only

°Õ°¿³ÝÌý890ÌýÌýDoctoral Preliminary ExaminationÌýÌý(1-9 credit hours)ÌýÌý

For students who are preparing for and taking written and/or oral preliminary exams.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý893ÌýÌýDoctoral Supervised ResearchÌýÌý(1-9 credit hours)ÌýÌý

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý895ÌýÌýDoctoral Dissertation ResearchÌýÌý(1-9 credit hours)ÌýÌý

Dissertation research.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

°Õ°¿³ÝÌý896ÌýÌýSummer Dissertation ResearchÌýÌý(1 credit hours)ÌýÌý

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

Prerequisite: Doctoral student

Typically offered in Summer only

°Õ°¿³ÝÌý899ÌýÌýDoctoral Dissertation PreparationÌýÌý(1-9 credit hours)ÌýÌý

For students who have completed all credit hour, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer