¸£Àû±ÆÕ¾

¸£Àû±ÆÕ¾ Catalog 2025-2026

Microbiology (MB)

²ÑµþÌý101/µþ°ä±áÌý101ÌýÌýIntroduction to Microbiology and Biochemistry Laboratory PracticesÌýÌý(3 credit hours)ÌýÌý

Curricular bridge between high school and college for high school and transitional students. A "hands on" introduction to fundamentals in Microbiology and Biochemistry. Bacterial isolation, identification and growth using aseptic technique, microscopy, and metabolic analysis. Experiments with DNA isolation and analysis, protein isolation, and purification, and enzyme kinetics. Lectures and readings on background, theory and applications of these techniques. Field trips to university and industry research laboratories. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS) as well as other pre-college, transitional and early-college programs and is offered as 4 week intensive course. Applicants should have completed high school courses in biology and chemistry. Students must have completed no more than 30 credit hours. Departmental approval is required for current NCSU students.

Typically offered in Summer only

²ÑµþÌý103ÌýÌýIntroductory Topics in MicrobiologyÌýÌý(1 credit hours)ÌýÌý

Introduction to scope and objectives of university education. Emphasis on microbiology. Career opportunities, computers, university resources.

Typically offered in Fall only

²ÑµþÌý180ÌýÌýIntroduction to Microbial BioprocessingÌýÌý(3 credit hours)ÌýÌý

Curricular bridge between high school and college for high school and transitional students. Fundamental cell biology concepts pertaining to biomanufacturing. Students gain an understanding of the basic principles of microbiology, culture preparation, physiology, and genetics of microbial cell cultures. Team-based decisions, collaborations and consideration of multiple perspectives are emphasized. Practical experience in laboratory and culture techniques used in biomanufacturing. Transportation will be provided for field trips. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS), as well as other pre-college, transitional and early-college programs. Suitable for students with less than 30 credit hours.

Typically offered in Summer only

²ÑµþÌý200ÌýÌýThe Fourth Horseman: Plagues that Changed the WorldÌýÌý(3 credit hours)ÌýÌý

An integrated and in-depth study of select microbial pathogens and their influence on history, public health, and human affairs. Five major pathogens will be examined to identify causative agents of disease, modes of transmission, prevention, and treatment. These pathogens will be framed in the power of plagues to shape human history and their impact on public health.

GEP Interdisciplinary Perspectives, GEP Natural Sciences

Typically offered in Fall, Spring, and Summer

²ÑµþÌý210/µþ±õ°ÕÌý210ÌýÌýPhage HuntersÌýÌý(3 credit hours)ÌýÌý

This course offers first-year students an opportunity for mentored research. Students will apply the scientific method to make novel discoveries. Students will isolate and characterize naturally-occurring bacteriophage (viruses that infect bacteria, but not humans) from the environment. They will present their data to each other, and the genome of one phage will be sequenced. Students have the option to continue in a second semester to annotate that genome, culminating in a submission to genbank and a poster presentation. Students in the course are part of the National Genome Research Initiative funded by The Howard Hughes Medical Institute. Student should have had a high school biology course before taking this course.

GEP Natural Sciences

Typically offered in Fall only

²ÑµþÌý211/µþ±õ°ÕÌý211ÌýÌýPhage GenomicsÌýÌý(2 credit hours)ÌýÌý

This course offers first-year students an opportunity for mentored research. Student will apply the scientific method to make novel discoveries. Students will build on the work they began in BIT/²ÑµþÌý210; The novel phage isolated in the previous semester will undergo genome sequencing over winter break, and in this course students will learn to analyze and annotate the genome sequence. This semester will culminate in a submission to genbank and a poster presentation. Students in the course are part of the national genome research initiative funded by the Howard Hughes Medical Institute.

Prerequisite: BIT(MB) 210

GEP Natural Sciences

Typically offered in Spring only

²ÑµþÌý251ÌýÌýGeneral MicrobiologyÌýÌý(3 credit hours)ÌýÌý

Introduction to basic principles of microbiology for all students. Before taking this course, students should understand the requirements of life including cell structure and function, central carbon metabolism, and flow of genetic information.

Prerequisite: (µþ±õ°¿Ìý181 or µþ±õ°¿Ìý183) and one Chemistry course

Typically offered in Fall, Spring, and Summer

²ÑµþÌý252ÌýÌýGeneral Microbiology LaboratoryÌýÌý(1 credit hours)ÌýÌý

A laboratory experience including development of skills such as aseptic technique, cultivation and identification of bacteria, staining, microscopy, and enumeration of microorganisms. A student successfully completing this course will demonstrate increased skills in scientific problem solving, data analysis, and communication. Cannot receive credit for both ²ÑµþÌý252 and ²ÑµþÌý254.

Corequisite: ²ÑµþÌý251

Typically offered in Fall and Spring

²ÑµþÌý254ÌýÌýInquiry-Guided Microbiology LabÌýÌý(1 credit hours)ÌýÌý

A laboratory experience for microbiology majors and honors students. Students will present findings of a semester-long research project in both written and oral formats. Students will develop skills such as aseptic technique, cultivation and identification of bacteria, staining, microscopy, and enumeration of microorganisms. A student successfully completing this course will demonstrate increased skills in scientific problem solving, data analysis, and communication. Credit is not allowed for both ²ÑµþÌý252 and ²ÑµþÌý254.

Corequisite: ²ÑµþÌý251

Typically offered in Fall and Spring

²ÑµþÌý311ÌýÌýMedical MicrobiologyÌýÌý(3 credit hours)ÌýÌý

This course will discuss medically important pathogens and their interaction with a human host. Students will examine the biology of microbial pathogens, including bacteria, viruses, fungi, and protozoa, along with the mechanisms of microbial pathogenesis and mammalian host immune responses to infections. The clinical characteristics and epidemiology of infectious diseases including transmission mechanisms, diagnosis, prevention, and treatment will be analyzed. Students should come into this course already familiar with biological properties of different types of microorganisms.

Prerequisite: ²ÑµþÌý251

Typically offered in Fall and Spring

²ÑµþÌý312ÌýÌýMedical Microbiology LaboratoryÌýÌý(1 credit hours)ÌýÌý

Laboratory experience to complement ²ÑµþÌý311. Students will gain hands-on experience with methods of culturing, identifying, and safe handling of pathogenic microorganisms. We will use clinical lab identification and research strategies to diagnose infection, track disease outbreaks, and answer research questions of clinical importance. Students should have previous experience with aseptic technique, micropipetting, and basic microbiological culturing methods.

Prerequisite: ²ÑµþÌý252 or ²ÑµþÌý254; Corequisite: ²ÑµþÌý311

Typically offered in Spring only

²ÑµþÌý360ÌýÌýScientific Inquiry in Microbiology: At the BenchÌýÌý(3 credit hours)ÌýÌý

Scientific questions, controls and variables, designing, preparing for and carrying out experiments, keeping a notebook, interpreting results, and presenting their findings: i.e. the pragmatic things a student must know in order to work efficiently in a research lab regardless of the discipline. Prior or current enrollment in MB 352 or MB 354 recommended.

Prerequisite:°ä±áÌý101 and µþ±õ°¿Ìý183 (both with a C- or better)

Typically offered in Fall only

²ÑµþÌý405/¹ó³§Ìý505/²ÑµþÌý505/¹ó³§Ìý405ÌýÌýFood MicrobiologyÌýÌý(3 credit hours)ÌýÌý

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing, and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/²ÑµþÌý405 and FS/²ÑµþÌý505.

Prerequisite: ²ÑµþÌý251

Typically offered in Fall only

²ÑµþÌý406/¹ó³§Ìý506/²ÑµþÌý506/¹ó³§Ìý406ÌýÌýFood Microbiology LabÌýÌý(2 credit hours)ÌýÌý

Laboratory experience to complement FS/²ÑµþÌý405 or FS/²ÑµþÌý505. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes, and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

Prerequisite: ²ÑµþÌý251 and (²ÑµþÌý252 or ²ÑµþÌý254) and Corequisite: ¹ó³§Ìý405

Typically offered in Fall only

²ÑµþÌý414ÌýÌýMicrobial Metabolic RegulationÌýÌý(3 credit hours)ÌýÌý

An integrative perspective on bacterial physiology and metabolism through an analysis of metabolic regulatory functions.

Prerequisite: MB 351 and either µþ°ä±áÌý351 or 451

Typically offered in Fall only

²ÑµþÌý420/²ÑµþÌý520ÌýÌýFundamentals of Microbial Cell BiotransformationsÌýÌý(2 credit hours)ÌýÌý

This is a half-semester course. Basic microbial cell culture theory and practice: cell physiology, mass balances, and metabolic control as seen in a dynamic bioreactor process to be scalable, consistent, and robust. The lab portion of the course provides students with hands-on experience in culture techniques using bioreactors. Students who have completed MB(BEC) 520 may not take BEC (MB) 420 for credit.

Prerequisite: MB 352 OR Corequisite of BEC(MB) 320

Typically offered in Fall only

²ÑµþÌý435/²ÑµþÌý535ÌýÌýBacterial PathogenesisÌýÌý(3 credit hours)ÌýÌý

Focuses on basic principles of bacterial pathogenesis, including mechanisms utilized by these microbes to attach/adhere, internalize or invade, and disseminate through their animal hosts. Bacterial strategies to subvert hos defenses and persist within their animal hosts defense mechanisms, and virulence gene regulation will also be discussed. Students cannot get credit for both ²ÑµþÌý435 and ²ÑµþÌý535. Graduate status required for ²ÑµþÌý535.

Prerequisite: MB 411, Graduate standing

Typically offered in Spring only

²ÑµþÌý441ÌýÌýImmunologyÌýÌý(3 credit hours)ÌýÌý

Introduction to principles of molecular immunology. Overview of immune system development and function, and discussions of ongoing scientific research regarding immune regulation.

P: C- or better in (MB 351 or µþ°ä±áÌý351 or µþ°ä±áÌý451 or µþ±õ°¿Ìý414 or PB 414 or BIO 421)

Typically offered in Fall and Spring

²ÑµþÌý451ÌýÌýMicrobial DiversityÌýÌý(3 credit hours)ÌýÌý

Molecular, biochemical, and evolutionary diversity of the microbial world, including Bacteria, Archaea, and Eukaryotes. Evolutionary perspective on microbial relationships, molecular methods of study and classical and modern biotechnological methods utilizing this genetic diversity to explore the microbial world and use the resulting insight to meet the needs of our own species.

Typically offered in Fall and Spring

²ÑµþÌý452ÌýÌýMicrobial Diversity LabÌýÌý(2 credit hours)ÌýÌý

This lab course is project-oriented. Students perform a series of classical enrichments and isolations, starting from environmental samples collected by the students themselves. Some of these isolations serve as the starting materials for a series of modern molecular biology experiments, in which students purify DNA, amplify ribosomal DNA by PCR, and have a portion of this gene sequenced. This sequence information is the starting point for the term project, a detailed molecular phylogenetic analysis of the isolated organisms. Students will be required to provide their own transportation during non-scheduled class time for local field sample collection.

Prerequisite: MB 412; Corequisite: ²ÑµþÌý451

Typically offered in Fall only

²ÑµþÌý455ÌýÌýMicrobial BiotechnologyÌýÌý(3 credit hours)ÌýÌý

Introduction to industrial microbiology with focus on biotechnology including developments employing recombinant nucleic acid and monoclonal antibody techniques. Bioremediation, industrial enzymes, transgenic plants, biopesticides, medical diagnostics, recombinant vaccines production of important secondary metabolites, and other topics. Field trips to local biotechnology companies.

Prerequisite: MB 351 and ³Ò±·Ìý311

Typically offered in Spring only

²ÑµþÌý461ÌýÌýMolecular VirologyÌýÌý(3 credit hours)ÌýÌý

Introduction to principles of molecular virology. Overview of classification and nomenclature, virus structure, interaction of viruses with cells, organisms (immunology, pathology), and populations (epidemiology). Detailed case studies from major groups of viruses; picornaviruses, togaviruses, orthomyxoviruses, retroviruses, polyomaviruses, and herpesviruses.

Prerequisite: MB 351, MB 411

Typically offered in Spring only

²ÑµþÌý470ÌýÌýEmerging and Re-emerging Infectious DiseasesÌýÌý(3 credit hours)ÌýÌý

Human behavior plays a big part in the emergence and reemergence of infectious diseases. Humanity encroaches consistently into previously uninhabited parts of the planet increasing the risk of exposure to novel pathogens that have the potential to jump into the human host or livestock. In addition to exposure to new diseases the complexities of politics and global relations often create opportunities for the re-emergence of infections that were once thought to be under control. This course aims to provide students interested in the health sciences with a foundation to understand the principles governing emergence of diseases.

Prerequisite: ²ÑµþÌý251

Typically offered in Spring only

²ÑµþÌý479/²ÑµþÌý579ÌýÌýMicrobial Symbiosis & MicrobiomesÌýÌý(3 credit hours)ÌýÌý

Microbial symbioses affect all life on earth. A recent surge of research has identified the critical role of microbial symbionts in maintaining host health and well-being, for example by mediating the breakdown of food for host nutrition, priming the immune system and directly fighting off pathogenic bacteria, and triggering key physiological outcomes associated with behavior and development. This course explores core topics in the study of microbial symbioses, including partner recognition and communication, adaptations to host association, the role of symbiosis in genome evolution and ecology, and the effects of microbial symbiosis on host health. Lectures and discussions will draw heavily from the primary literature in the field of microbiome/symbiosis research, focusing on the most recent discoveries, key methodological advancements, and on diverse associations ranging from marine symbioses to the human microbiome.

Prerequisite: MB 351 General Microbiology

Typically offered in Fall only

²ÑµþÌý480ÌýÌýCurrent Issues in MicrobiologyÌýÌý(1 credit hours)ÌýÌý

Library research on current topics in all areas of microbiology. Presentation of research results orally and in the form of a major term paper.

Prerequisite: SMB majors or minors, Senior standing, and MB 351

Typically offered in Fall and Spring

²ÑµþÌý492ÌýÌýExternal Learning ExperienceÌýÌý(1-6 credit hours)ÌýÌý

A learning experience in agriculture and life sciences within an academic framework that utilizes facilities and resources which are external to the campus. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and the academic dean prior to the experience.

Prerequisite: Sophomore standing

Typically offered in Fall, Spring, and Summer

²ÑµþÌý501/±Ê±ÊÌý501/±ÊµþÌý501ÌýÌýBiology of Plant PathogensÌýÌý(3 credit hours)ÌýÌý

Biology of microbes that cause plant diseases. The ecology, genetics, physiology, taxonomy, and mechanisms of parasitism, pathogenicity and virulence of bacteria (and other prokaryotes), fungi (and oomycetes), nematodes, and viruses that cause plant diseases. Prepares graduate students for advanced courses in plant pathology, host-parasite interactions, and provides a knowledge base for students in other disciplines involved with plant pathogens or who seek to broaden their knowledge of microbes.

Prerequisite: ±Ê±ÊÌý315, or ±Ê±ÊÌý318, or an introductory course in microbiology

Typically offered in Fall only

²ÑµþÌý505/¹ó³§Ìý405/²ÑµþÌý405/¹ó³§Ìý505ÌýÌýFood MicrobiologyÌýÌý(3 credit hours)ÌýÌý

Microorganisms of importance in foods and their metabolic activities. Source of microbial contamination during food production, processing, and storage. Microbial spoilage; foods as vectors of human pathogens. Physical and chemical destruction of microorganisms in foods and the kinetics involved. Conversions of raw foods by microorganisms into food products. Microbiological standards for regulatory and trade purposes. Credit will not be given for both FS/²ÑµþÌý405 and FS/²ÑµþÌý505.

Prerequisite: ²ÑµþÌý251

Typically offered in Fall only

²ÑµþÌý506/¹ó³§Ìý406/²ÑµþÌý406/¹ó³§Ìý506ÌýÌýFood Microbiology LabÌýÌý(2 credit hours)ÌýÌý

Laboratory experience to complement FS/²ÑµþÌý405 or FS/²ÑµþÌý505. Skills in detecting and quantitating microorganisms and their toxins in foods. Application of colony and direct microscopic counts, most probable numbers, enzyme immunoassays, nucleic acid probes, and computer modeling are used to understand the numbers and types of microorganisms or microbial end products in foods. Laboratory safety and oral and written reports are emphasized.

Prerequisite: ²ÑµþÌý251 and (²ÑµþÌý252 or ²ÑµþÌý254) and Corequisite: ¹ó³§Ìý405

Typically offered in Fall only

²ÑµþÌý520/²ÑµþÌý420ÌýÌýFundamentals of Microbial Cell BiotransformationsÌýÌý(2 credit hours)ÌýÌý

This is a half-semester course. Basic microbial cell culture theory and practice: cell physiology, mass balances, and metabolic control as seen in a dynamic bioreactor process to be scalable, consistent, and robust. The lab portion of the course provides students with hands-on experience in culture techniques using bioreactors. Students who have completed MB(BEC) 520 may not take BEC (MB) 420 for credit.

Prerequisite: MB 352 OR Corequisite of BEC(MB) 320

Typically offered in Fall only

²ÑµþÌý532/³§³§°äÌý532ÌýÌýSoil MicrobiologyÌýÌý(3 credit hours)ÌýÌý

Soil as a medium for microbial growth, the relation of microbes to important mineral transformations in soil, the importance of biological equilibrium and significance of soil microbes to environmental quality.

Prerequisite: MB 351, °ä±áÌý220

Typically offered in Spring only

²ÑµþÌý535/²ÑµþÌý435ÌýÌýBacterial PathogenesisÌýÌý(3 credit hours)ÌýÌý

Focuses on basic principles of bacterial pathogenesis, including mechanisms utilized by these microbes to attach/adhere, internalize or invade, and disseminate through their animal hosts. Bacterial strategies to subvert hos defenses and persist within their animal hosts defense mechanisms, and virulence gene regulation will also be discussed. Students cannot get credit for both ²ÑµþÌý435 and ²ÑµþÌý535. Graduate status required for ²ÑµþÌý535.

Prerequisite: MB 411, Graduate standing

Typically offered in Spring only

²ÑµþÌý555ÌýÌýMicrobial BiotechnologyÌýÌý(3 credit hours)ÌýÌý

Overview of industrial microbiology focusing on current biotechnology methods (bacteria, yeast, fungi) employing rDNA, optimization of heterologous gene expression, microbial metabolic pathway engineering, metabolomics, protein engineering and recombinant antibodies. Genetic and pathway engineering strategies for developing new microbes to screen for new therapeutic compounds or overproduce: primary metabolites, antibiotics, biotherapeutic proteins, industrially useful enzymes, medical diagnostics, recombinant vaccines, biopolymers. Utilization of biofilms, methods to immobilize biocatalysts, and microbial kinetics are also covered. Field trip to local biotechnology company. Students cannot receive credit for both 455 and 555.

Prerequisite: Undergraduate microbiology, genetics, and biochemistry course: MB351, µþ°ä±áÌý351, and ³Ò±·Ìý311

Typically offered in Spring only

²ÑµþÌý575/±Ê±ÊÌý575/±ÊµþÌý575ÌýÌýIntroduction to MycologyÌýÌý(4 credit hours)ÌýÌý

A survey of the fungal kingdom in context of phyla and classes. Systematics, ecology, biology and utilization. Illustrative material, cultural techniques in laboratories. Collection and paper required.

Prerequisite: BS 125 or BS 181 and 183 or BO 200 or ±Ê±ÊÌý315 or ±Ê±ÊÌý318

Typically offered in Fall only

This course is offered alternate odd years

²ÑµþÌý579/²ÑµþÌý479ÌýÌýMicrobial Symbiosis & MicrobiomesÌýÌý(3 credit hours)ÌýÌý

Microbial symbioses affect all life on earth. A recent surge of research has identified the critical role of microbial symbionts in maintaining host health and well-being, for example by mediating the breakdown of food for host nutrition, priming the immune system and directly fighting off pathogenic bacteria, and triggering key physiological outcomes associated with behavior and development. This course explores core topics in the study of microbial symbioses, including partner recognition and communication, adaptations to host association, the role of symbiosis in genome evolution and ecology, and the effects of microbial symbiosis on host health. Lectures and discussions will draw heavily from the primary literature in the field of microbiome/symbiosis research, focusing on the most recent discoveries, key methodological advancements, and on diverse associations ranging from marine symbioses to the human microbiome.

Prerequisite: MB 351 General Microbiology

Typically offered in Fall only

²ÑµþÌý585ÌýÌýBiotechnology Industry Practicum IÌýÌý(3 credit hours)ÌýÌý

Project-based course directly working with biotechnology and pharmaceutical companies. Students work in teams on a company-specific project. Projects range from developing business or marketing plans for new products; writing Small Business Innovation Research (SBIR) grants or white papers; creating procedures, protocols, and/or process improvements for a company-specific process; and studying intellectual property issues. Written and oral communication skills as well as teamwork, flexibility, and ambiguity management are emphasized. Restricted to MBT students.

Restriction: enrollment in the Master of Microbial Biotechnology Program required

Typically offered in Fall only

²ÑµþÌý586ÌýÌýBiotechnology Industry Practicum IIÌýÌý(3 credit hours)ÌýÌý

This is a project-based course directly working with small (fewer than 500 employees) biotechnology and pharmaceutical companies. It builds on knowledge and skills introduced in ²ÑµþÌý585, but with increased independence and autonomy. The class will further explore issues in biotechnology including funding, intellectual property, regulatory affairs, and commercialization. Students work in teams on a company-specific project with input from their industry mentor. In addition, students will participate in the campus-wide CATALYZE Conference pitch competition. Written, oral, and visual communication skills as well as teamwork, flexibility, and ambiguity management are emphasized. Restricted to MMB students.

Prerequisite: ²ÑµþÌý585 and restricted to students enrolled in the Master of Microbial Biotechnology Program

Typically offered in Spring only

²ÑµþÌý587ÌýÌýBiotechnology Industry Practicum IIIÌýÌý(3 credit hours)ÌýÌý

This course builds on ²ÑµþÌý585 and 586, placing the students in this course in leadership and mentoring roles in their team projects. Students work with faculty innovators and industry mentors on real-world questions such as market analyses, patent searching, strategic partnerships, and supply chain networks. At the start of the semester, student teams work on a 5-week project with an NC State innovator, followed by a 10-week project with participating companies, meeting with their industry mentor on a regular schedule. In addition, students will begin the ideation process for their capstone projects using a Design Thinking Framework. Students will participate in an ideation workshop, brainstorm unmet needs relevant to the biotechnology industry, explore possible solutions, and delve into the desirability, feasibility, and sustainability of their ideas as a jumping point for the MMB capstone course. Restricted to MMB students.

Prerequisite: ²ÑµþÌý586 and enrollment in the MMB program

Typically offered in Fall only

²ÑµþÌý588/µþ±õ°ÕÌý588ÌýÌýMicrobiome AnalysisÌýÌý(3 credit hours)ÌýÌý

Microbiomes are increasingly recognized for their important roles in ecosystem services ranging from human health to soil biogeochemical cycling. Studying these complex communities relies on DNA sequencing, which often generates large, sparse datasets. Students will be introduced to conceptual and practical aspects of how to analyze microbiome data, and will apply both bioinformatics and statistical approaches. Topics include identifying microbial sequence variants, exploratory analysis of microbial community diversity and structure, applying hypothesis testing to complex microbiome data, and reproducible research.

Prerequisite: Graduate Standing

Typically offered in Spring only

²ÑµþÌý589ÌýÌýMaster of Microbial Biotechnology CapstoneÌýÌý(3 credit hours)ÌýÌý

²ÑµþÌý589 is a graduate-level course required for the MMB Program in the final semester. In this course, students integrate skills and knowledge acquired through the ²ÑµþÌý585 industry practicum experience to identify an unmet need and to evaluate the feasibility of a novel product or service generated through their own ideation process. They develop a comprehensive, customer-validated business model and create an investor pitch for both the solution and the company that will provide the solution.

Requisite: MMB Program with successful completion of three semesters of ²ÑµþÌý585 and in good academic standing

Typically offered in Spring only

²ÑµþÌý590ÌýÌýTopical ProblemsÌýÌý(1-3 credit hours)ÌýÌý

Informal group discussion of prepared topics assigned by instructor.

Prerequisite: Graduate standing

²ÑµþÌý601ÌýÌýSeminarÌýÌý(1 credit hours)ÌýÌý

Weekly seminars on topics of current interest given by resident faculty members, graduate students and visiting lecturers.

Typically offered in Fall only

²ÑµþÌý610ÌýÌýSpecial Topics MicrobiologyÌýÌý(1-6 credit hours)ÌýÌý

The study of special problems and selected topics of current interest in microbiology and related fields.

Typically offered in Fall, Spring, and Summer

²ÑµþÌý620ÌýÌýSpecial ProblemsÌýÌý(1-6 credit hours)ÌýÌý

Selection of a subject by each student on which to do research and write a technical report on the results. The individual may choose a subject pertaining to his or her particular interest in any area of study in microbiology.

Typically offered in Fall, Spring, and Summer

²ÑµþÌý624ÌýÌýTopical ProblemsÌýÌý(1-3 credit hours)ÌýÌý

Prerequisite: Graduate standing

Typically offered in Spring only

²ÑµþÌý670ÌýÌýLaboratory Research MethodsÌýÌý(1-3 credit hours)ÌýÌý

Directed research of microbiology graduate students in departmental laboratories prior to selecting thesis research topic. Selection of a minimum of three laboratories for research experience lasting 3 to 5 weeks. Acquisition of research methods relevant to each laboratory. Microbiology graduate students only.

Typically offered in Fall only

²ÑµþÌý680ÌýÌýMicrobiology Research PresentationsÌýÌý(1 credit hours)ÌýÌý

Essential elements of structure, delivery, and data visualization in scientific research presentations. Hands-on training in scientific communication across microbiology research fields and evaluation of student seminars based on ongoing or proposed microbiology research projects. Coverage of cutting-edge microbiology research topics as determined by instructor. Microbiology graduate students only.

Prerequisite: Graduate Standing

Typically offered in Fall only

²ÑµþÌý685ÌýÌýMaster's Supervised TeachingÌýÌý(1-3 credit hours)ÌýÌý

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý686ÌýÌýTeaching ExperienceÌýÌý(1 credit hours)ÌýÌý

Faculty mentoring in didactic and methodological aspects of teaching, including instructional technology as well as design and grading of assessment instruments. Provision of individual performance evaluations to encourage enhancement of teaching skills. Microbiology graduate students only.

Prerequisite: Microbiology Graduate student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý688ÌýÌýNon-Thesis Masters Continuous Registration - Half Time RegistrationÌýÌý(1 credit hours)ÌýÌý

For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain half-time continuous registration to complete incomplete grades, projects, final master's exam, etc.

Prerequisite: Master's student

Typically offered in Summer only

²ÑµþÌý689ÌýÌýNon-Thesis Master Continuous Registration - Full Time RegistrationÌýÌý(3 credit hours)ÌýÌý

For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain full-time continuous registration to complete incomplete grades, projects, final master's exam, etc. Students may register for this course a maximum of one semester.

Prerequisite: Master's student

Typically offered in Summer only

²ÑµþÌý690ÌýÌýMaster's ExaminationÌýÌý(1-9 credit hours)ÌýÌý

For students in non thesis master's programs who have completed all other requirements of the degree except preparing for and taking the final master's exam.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý693ÌýÌýMaster's Supervised ResearchÌýÌý(1-9 credit hours)ÌýÌý

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý695ÌýÌýMaster's Thesis ResearchÌýÌý(1-9 credit hours)ÌýÌý

Thesis research.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý696ÌýÌýSummer Thesis ResearchÌýÌý(1 credit hours)ÌýÌý

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

Prerequisite: Master's student

Typically offered in Summer only

²ÑµþÌý699ÌýÌýMaster's Thesis PreparationÌýÌý(1-9 credit hours)ÌýÌý

For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their theses.

Prerequisite: Master's student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý714ÌýÌýMicrobial Metabolic RegulationÌýÌý(3 credit hours)ÌýÌý

An integrative perspective on bacterial physiology and metabolism through analysis of metabolic regulatory functions.

Prerequisite: MB 351 and either µþ°ä±áÌý351 or 451

Typically offered in Fall only

²ÑµþÌý715/±Ê±ÊÌý715ÌýÌýApplied Evolutionary Population GeneticsÌýÌý(3 credit hours)ÌýÌý

This course will introduce students to nonparametric and model-based methods for making inferences on population processes (i.e., mutation, migration, drift, recombination, and selection). The goal is to provide a conceptual overview of these methods in lectures and hands-on training on how to analyze and interpret sample data sets in guided computer lab sessions. The course will leverage the tools and resources implemented in the DeCIFR toolkit (https://decifr.cifr.ncsu.edu/). DeCIFR is a comprehensive suite of biodiversity informatics pipelines and visualization tools to discover, evaluate, and describe taxa at multiple spatial and phylogenetic scales. Students will apply these tools to estimate population parameters in different organisms with a focus on eukaryotic microbes, viruses, and bacteria.

Typically offered in Fall only

²ÑµþÌý718ÌýÌýIntroductory VirologyÌýÌý(3 credit hours)ÌýÌý

Introduction to principles of virology including: classification and nomenclature, epidemiology, structure, genome replication, gene expression strategies and cellular infection cycle. Major groups of viruses including those with DNA genomes and positive-sense or negative-sense RNA genomes.

Prerequisite: µþ°ä±áÌý451 or GN 411 or MB 351

Typically offered in Fall only

This course is offered alternate odd years

²ÑµþÌý725/¹ó³§Ìý725ÌýÌýFermentation MicrobiologyÌýÌý(3 credit hours)ÌýÌý

Fermentation bioprocessing and characteristics, function and ecology of responsible microorganisms. Fermentative activities, growth responses and culture interactions related to metabolism, physiology and genetics of lactic acid bacteria and selected yeasts and molds. Current developments in starter culture technology and genetics; application to food and industrial fermentations.

Prerequisite: µþ°ä±áÌý451, MB 351

Typically offered in Spring only

This course is offered alternate years

²ÑµþÌý751/±õ²Ñ²ÑÌý751ÌýÌýImmunologyÌýÌý(3 credit hours)ÌýÌý

Introduction to mechanisms of immunity in man and animals. Emphasis on interactions between cells of the immune system in production of immune responses and the molecules in control of these interactions.

Prerequisite: µþ°ä±áÌý451, GN 411, MB 351

Typically offered in Spring only

²ÑµþÌý758/³Ò±·Ìý758ÌýÌýMicrobial Genetics & GenomicsÌýÌý(3 credit hours)ÌýÌý

Structure and function in microbial genetics, with emphasis on microbial genome organization, stable maintenance and evolution. DNA mutation and repair pathways, transcriptional and translational regulation, DNA replication and recombination and characterization of recombinant DNA molecules. Applications of genetic and genomic analysis methods to microbial processes, including strain construction, genome manipulation, and enhancement of gene expression.

Typically offered in Spring only

²ÑµþÌý774/±ÊµþÌý774ÌýÌýPhycologyÌýÌý(3 credit hours)ÌýÌý

Introduction to taxonomy, morphology, reproduction and ecological importance of organisms which may be included in the algae. Attention to local freshwater flow and physiology of selected species in relation to algal blooms, water quality and nutrient loading in aquatic habitats.

Typically offered in Spring only

This course is offered alternate odd years

²ÑµþÌý783/°äµþ³§Ìý783/±õ²Ñ²ÑÌý783ÌýÌýAdvanced ImmunologyÌýÌý(3 credit hours)ÌýÌý

In depth study of the basic cellular and molecular mechanisms of immunity, including antigen processing and presentation, T cell development, initiation of the immune response, effector mechanisms, and immunological memory. The course is designed for advanced graduate students who wish to focus on the current concepts in immunology.

Prerequisite: MB (IMM) 751

Typically offered in Fall only

This course is offered alternate odd years

²ÑµþÌý790ÌýÌýTopical ProblemsÌýÌý(1-3 credit hours)ÌýÌý

Typically offered in Fall, Spring, and Summer

²ÑµþÌý801ÌýÌýSeminarÌýÌý(1 credit hours)ÌýÌý

Weekly seminars on topics of current interest given by resident faculty members, graduate students and visiting lecturers.

Typically offered in Fall and Spring

²ÑµþÌý810ÌýÌýSpecial Topics MicrobiologyÌýÌý(1-6 credit hours)ÌýÌý

The study of special problems and selected topics of current interest in microbiology and related fields.

Typically offered in Fall, Spring, and Summer

²ÑµþÌý820ÌýÌýSpecial ProblemsÌýÌý(1-6 credit hours)ÌýÌý

Selection of a subject by each student on which to do research and write a technical report on the results. The individual may choose a subject pertaining to his or her particular interest in any area of study in microbiology.

Typically offered in Summer only

²ÑµþÌý824ÌýÌýTopical ProblemsÌýÌý(1-3 credit hours)ÌýÌý

Prerequisite: Graduate standing

Typically offered in Spring only

²ÑµþÌý870ÌýÌýDoctoral Lab RotationsÌýÌý(1-3 credit hours)ÌýÌý

Directed research of microbiology graduate students in departmental laboratories prior to selecting thesis research topic. Selection of a minimum of three laboratories for research experience lasting 3 to 5 weeks. Acquisition of research methods relevant to each laboratory. Microbiology graduate students only.

Typically offered in Fall only

²ÑµþÌý880ÌýÌýDoctoral Microbiology Research PresentationsÌýÌý(1 credit hours)ÌýÌý

Essential elements of structure, delivery, and data visualization in scientific research presentations. Hands-on training in scientific communication across microbiology research fields and evaluation of student seminars based on ongoing or proposed microbiology research projects. Coverage of cutting-edge microbiology research topics as determined by instructor. Microbiology graduate students only.

R: Graduate Standing

Typically offered in Fall only

²ÑµþÌý885ÌýÌýDoctoral Supervised TeachingÌýÌý(1-3 credit hours)ÌýÌý

Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý886ÌýÌýTeaching ExperienceÌýÌý(1 credit hours)ÌýÌý

Faculty mentoring in didactic and methodological aspects of teaching, including instructional technology as well as design and grading of assessment instruments. Provision of individual performance evaluations to encourage enhancement of teaching skills. Microbiology graduate students only.

Prerequisite: Microbiology Graduate student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý890ÌýÌýDoctoral Preliminary ExaminationÌýÌý(1-9 credit hours)ÌýÌý

For students who are preparing for and taking written and/or oral preliminary exams.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý893ÌýÌýDoctoral Supervised ResearchÌýÌý(1-9 credit hours)ÌýÌý

Instruction in research and research under the mentorship of a member of the Graduate Faculty.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý895ÌýÌýDoctoral Dissertation ResearchÌýÌý(1-9 credit hours)ÌýÌý

Dissertation research.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer

²ÑµþÌý896ÌýÌýSummer Dissertation ResearchÌýÌý(1 credit hours)ÌýÌý

For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.

Prerequisite: Doctoral student

Typically offered in Summer only

²ÑµþÌý899ÌýÌýDoctoral Dissertation PreparationÌýÌý(1-9 credit hours)ÌýÌý

For students who have completed all credit hour, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.

Prerequisite: Doctoral student

Typically offered in Fall, Spring, and Summer